Dr. Sophie Pénisson (Univ. Paris-Est Créteil)
We present a mathematical model of tumor evolution that includes all phases in the life of a tissue, from tissue development to cancer occurrence. The effects of a carrying capacity, different types of cell division, and different types of driver mutations are also accounted for. New analytical closed-form expressions are obtained from this mechanistic model, providing a simple probability distribution for the timing of a highly complex evolutionary process. The results of the mathematical model are then used to provide key insights into cancer etiology, by assessing the role played by normal endogenous mutational processes.
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