2023 | Model-Informed Target Morning 17α-Hydroxyprogesterone Concentrations in Dried Blood Spots for Pediatric Congenital Adrenal Hyperplasia Patients | V. Stachanow, U. Neumann, O. Blankenstein, N. Alder-Baerens, D. Bindellini, P. Hindmarsh, R.J. Ross, M.J. Whitaker, J. Melin, W. Huisinga, R. Michelet, C. Kloft
Zeitschrift: Pharmaceuticals
Seiten: 464
Band: 16(3)
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2022 | Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion | Y. M. Nasser, N. Hohmann, R. Michelet, K. Gottwalt, A. D. Meid, J. Burhenne, W. Huisinga, W. E. Haefeli, G. Mikus, C. Kloft
Zeitschrift: Clinical Pharmacokinetics
Reihe: 61
Seiten: 1595–1607
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2022 | High-dosage fosfomycin results in adequate plasma and target-site exposure in morbidly obese and nonobese nonhyperfiltration patients | D. Busse, P. Simon, D. Petroff, N. El-Najjar, L. Schmitt, D. Bindellini, A. Dietrich, M. Zeitlinger, W. Huisinga, R. Michelet, H. Wrigge, C. Kloft
Zeitschrift: Antimicrob. Agents Chemother.
Seiten: e0230221
Band: 66
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2022 | Comparative plasma and interstitial tissue fluid pharmacokinetics of meropenem demonstrate the need for increasing dose and infusion duration in obese and non-obese patients | D. Busse, P. Simon, L. Schmitt, D. Petroff, C. Dorn, A. Dietrich, M. Zeitlinger, W. Huisinga, R. Michelet, H. Wrigge, C. Kloft
Zeitschrift: Clin. Pharmacokinet.
Seiten: 655-672
Band: 61
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2022 | Evaluation of a meropenem and piperacillin monitoring program in intensive care unit patients calls for the regular assessment of empirical targets and easy-to-use dosing decision tools | F.A. Weinelt, M.S. Stegemann, A. Theloe, F. Pfäfflin, S. Achterberg, F. Weber, L. Dübel, A. Mikolajewska, A. Uhrig, P. Kiessling, W. Huisinga, R. Michelet, S. Hennig, C. Kloft
Zeitschrift: Antibiotics
Seiten: 758
Band: 11(6)
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2021 | Mit Mathematik zur individuellen Therapie | W. Huisinga, C. Maier
Buchtitel: M. Ehrhardt, M. Günther und W. Schilders: Erfolgsformeln - Anwendungen der Mathematik
Seiten: 27-32
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2021 | Quantification of microdialysis related variability in humans: Clinical trial design recommendations | D. Busse, P. Simon, R. Michelet, L. Ehmann, F. Mehner, C. Dorn, A. Kratzer, W. Huisinga, H. Wrigge, D. Petroff, C. Kloft
Zeitschrift: European Journal of Pharmaceutical Sciences
Seiten: 105607
Band: 157
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2021 | Infliximab clearance decreases in second and third trimesters of pregnancy in inflammatory bowel disease | A.M. Grisic, M. Dorn-Rasmussen, B. Ungar, J. Brynskov, J.F. Ilvemark, N. Bolstad, D.J. Warren, M.A. Ainsworth, W. Huisinga, S. Ben-Horin, C. Kloft, C. Steenholdt
Zeitschrift: United Eur. Gastroenterol. J.
Seiten: 91-101
Band: 9
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2021 | Evaluation of the MeroRisk Calculator, a user-friendly tool to predict the risk of meropenem target non-attainment in critically ill patients | U. Liebchen, M. Klose, M. Paal, M. Vogeser, M. Zoller, I. Schroeder, L. Schmitt, W. Huisinga, R. Michelet, J. Zander, C. Scharf, F. Weinelt, C. Kloft
Zeitschrift: Antibiotics
Reihe: 10
Seiten: 468
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2021 | Similar piperacillin/tazobactam target attainment in obese versus nonobese patients despite differences in interstitial tissue fluid pharmacokinetics | D. Busse, P. Simon, D. Petroff, C. Dorn, L. Schmitt, D. Bindellini, A. Kratzer, A. Dietrich, M. Zeitlinger, W. Huisinga, R. Michelet, H. Wrigge, C. Kloft
Zeitschrift: Pharmaceuticals
Reihe: 13
Seiten: 1380
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2021 | Early survival prediction framework in CD19-specific CAR-T-cell immunotherapy using a population quantitative systems pharmacology model | A. Mueller-Schoell, N. Puebla-Osorio, R. Michelet, M. Green, A. Künkele, W. Huisinga, P. Strati, B. Chasen, S.S. Neelapu, C. Yee, C. Kloft
Zeitschrift: Cancers
Reihe: 13
Seiten: 2782
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2021 | Perspectives on model-informed precision dosing in the digital health era: Challenges, opportunities, and recommendations | F. Kluwe, R. Michelet, A. Mueller-Schoell, C. Maier, L. Klopp-Schulze, M. van Dyk, G. Mikus, W. Huisinga, C. Kloft
Zeitschrift: Clinical Pharmacology & Therapeutics
Seiten: 29-36
Band: 109
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2020 | Response to ‘Hydrocortisone suspension formulations are not necessarily the same in the treatment of children with congenital adrenal hyperplasia’. | R. Michelet, J. Melin, Z.P. Parra-Guillen, U. Neumann, M.J. Whitaker, V. Stachanow, W. Huisinga, J. Porter, O. Blankenstein, R.J. Ross, C. Kloft
Zeitschrift: European Journal of Endocrinology
Seiten: L29-L30
Band: 183
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2020 | Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children | R. Michelet, J. Melin, Z.P. Parra-Guillen, U. Neumann, M.J. Whitaker, V. Stachanow, W. Huisinga, J. Porter, O. Blankenstein, R.J. Ross, C. Kloft
Zeitschrift: European Journal of Endocrinology
Seiten: 357–368
Band: 183
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2020 | Obesity Alters Endoxifen Plasma Levels in Young Breast Cancer Patients: A Pharmacometric Simulation Approach | A. Mueller‐Schoell, L. Klopp‐Schulze, W. Schroth, T. Mürdter, R. Michelet, H. Brauch, W. Huisinga, M. Joerger, P. Neven, S.L.W. Koolen, R.H.J. Mathijssen, E. Copson, D. Eccles, S. Chen, B. Chowbay, A. Tfayli, N.K. Zgheib, M. Schwab, C. Kloft
Zeitschrift: Clinical Pharmacology & Therapeutics
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2019 | Comment on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharmaceutical Statistics 17 (5):593–606, Sep/Oct 2018, DOI: 10.1002/pst.1873 | A. Krause, C. Kloft, W. Huisinga, M. Karlsson, J. Pinheiro, R. Bies, J. Rogers, F. Mentré, B.J. Musser, ASA Special Interest Group on Statistics and Pharmacometrics/ASA Special Interest Group on Statistics and Pharmacometrics (SIG SxP)
Zeitschrift: Pharmaceutical Statistics
Seiten: 278–281
Band: 18
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2017 | Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: A prospective observational study | L. Ehmann, M. Zoller, I. K. Minichmayr, C. Scharf, B. Maier, M. V. Schmitt, N. Hartung, W. Huisinga, M. Vogeser, L. Frey, J. Zander, C. Kloft
Zeitschrift: Critical Care
Seiten: 263
Band: 21
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2017 | Model Description Language (MDL): A Standard for Modelling and Simulation | M. Smith, S. Moodie, R. Bizzotto, E. Blaudez, E. Borella, L. Carrara, P. Chan, M. Chenel, E. Comets, R. Gieschke, K. Harling, L. Harnisch, N. Hartung, A. Hooker, M. Karlsson, R. Kaye, C. Kloft, N. Kokash, M. Lavielle, G. Lestini, P. Magni, A. Mari, F. Men
Zeitschrift: CPT: Pharmacometrics & Systems Pharmacology
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,
doi:10.1002/psp4.12222
2015 | Target driven pharmacokinetics of biopharmaceutics | W. Huisinga, S. Fuhrmann, L. Fronton, B.F. Krippendorff
Verlag: Wiley
Buchtitel: 'Therapeutic Proteins – ADME and translational PK/PD in discovery and development', H. Zhou and F.-P. Theil (Eds.), ISBN 978-1-118-89864-2
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2011 | Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock | S. Unverzagt, M.-T. Machemer, A. Solms, H. Thiele, D. Burkhoff, M. Seyfarth, A. de Waha, E. Magnus Ohman, Michael Buerke, Johannes Haerting, Karl Werdan, Roland Prondzinsky
Zeitschrift: Cochrane Database of Systematic Reviews 6, CD007398
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2006 | Computational Physiology | W. Huisinga
Zeitschrift: European Communications in Mathematical and Theoretical Biology, No. 8, January 2006
Seiten: 12-13
Band: 8
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2006 | Adaptive Approach for Modelling Variability in Pharmacokinetics | A. Weiße, I. Horenko, and W. Huisinga
Reihe: Lecture Notes in Computer Science
Verlag: Springer
Buchtitel: 'Computational Life Sciences II', M.R. Berthold, R. Glen, and I. Fischer (Eds.)
Seiten: 194-204
Band: 4216
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2006 | Software Supported Modelling in Pharmacokinetics | R. Telgmann, M. von Kleist, and W. Huisinga
Reihe: Lecture Notes in Computer Science
Verlag: Springer
Buchtitel: 'Computational Life Sciences II', M.R. Berthold, R. Glen, and I. Fischer (Eds.)
Seiten: 216-225
Band: 4216
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2005 | Metastability and Dominant Eigenvalues of Transfer Operators | W. Huisinga, B. Schmidt
Reihe: Lecture Notes in Computational Science and Engineering
Verlag: Springer
Buchtitel: 'Advances in Algorithms for Macromolecular Simulation', C. Chipot, R. Elber, A. Laaksonen, B. Leimkuhler, A. Mark, T. Schlick, C. Schütte, and R. Skeel (Eds.)
Band: 49
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2003 | Metastability of Diffusion Processes | Ch. Schütte, W. Huisinga, S. Meyn
Buchtitel: Proceeding of the IUTAM Symposium on Nonlinear Stochastic Dynamics (August 26 - August 30, 2002, Illinois/USA)
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2003 | Biomolecular Conformations can be Identified as Metastable Sets of Molecular Dynamics | Ch. Schütte, W. Huisinga
Buchtitel: 'Handbook of Numerical Analysis' edited by P. G. Ciarlet, Special Volume: Computational Chemistry (Vol X) , guest editor C. Le Bris
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2000 | On Conformational Dynamics induced by Langevin Processes | Ch. Schütte, W. Huisinga
Buchtitel: 'International Conference on Differential Equations (EquaDiff 99)', edited by B. Fiedler K. Gröger and J. Sprekels, Vol.2 (2000)
Seiten: 1247-1262
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2000 | Biomolecular Conformations as Metastable Sets of Markov Chains | Ch. Schütte, W. Huisinga
Buchtitel: Proceedings of the 38th. Annual Allerton Conference on Communication, Control, and Computing, Oct. 4-6, Allerton House, Monticello, Illinoins/USA (2000)
Seiten: 1106-1115
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